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UniProt functional annotation for P32357 | ||
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| UniProt code: P32357. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. Involved in splicing pre-mRNA of the A1 cistron and other genes that are important for cell growth. {ECO:0000269|PubMed:11720285, ECO:0000269|PubMed:1922071}. |
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| Subunit: | |
Heterodimer (Probable). Interacts with PRP8 (via RNase H homology domain and MPN domain), competing with BRR2 for the same binding site. Component of a U5 snRNP complex that contains at least the U5 snRNA, PRP8, SNU114, AAR2, SMB1, SMD1, SMD2, SMD3, SME1, SMX2 and SMX3, but is not a component of the U4/U6-U5 tri-snRNP complex. {ECO:0000269|PubMed:11720285, ECO:0000269|PubMed:21764848, ECO:0000269|PubMed:23354046, ECO:0000305}. |
| Subcellular location: | |
Cytoplasm. Nucleus. Note=This protein lacks a nuclear localization signal, it may interact in the cytoplasm with a component of spliceosomes via the leucine-zipper and then be transported into the nucleus. |
| Ptm: | |
Phosphorylated on serine and tyrosine residues. {ECO:0000269|PubMed:21764848}. |
| Miscellaneous: | |
Present with 7330 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the AAR2 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.