UniProt functional annotation for P49190

UniProt code: P49190.

Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Function:		This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity). {ECO:0000250}.
Subunit:		Binds to TIPF39/TIP39.
Subcellular location:		Cell membrane; Multi-pass membrane protein.
Tissue specificity:		Expressed abundantly in brain and pancreas. Also expressed in the testis. {ECO:0000269|PubMed:7797535}.
Similarity:		Belongs to the G-protein coupled receptor 2 family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.