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UniProt functional annotation for Q99500 | ||
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| UniProt code: Q99500. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. {ECO:0000269|PubMed:10617617}. |
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| Subcellular location: | |
Cell membrane; Multi-pass membrane protein. |
| Tissue specificity: | |
Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver. |
| Similarity: | |
Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}. |
Annotations taken from UniProtKB at the EBI.