UniProt functional annotation for Q8IZF4



	UniProt functional annotation for Q8IZF4

UniProt code: Q8IZF4.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking). {ECO:0000250|UniProtKB:Q3V3Z3, ECO:0000305|PubMed:25713288}.

Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q3V3Z3}; Multi-pass membrane protein {ECO:0000305|PubMed:25713288}.

Tissue specificity: Expressed in immune cells. Primarily found in granulocytes. Found in eosinophils. {ECO:0000269|PubMed:21724806}.

Ptm: Autoproteolysis between residues Leu-226 and Thr-227 occurs in the lumen of the endoplasmic reticulum during receptor biosynthesis. The N- terminal fragment (NTF) subsequently reassociates with the C-terminal fragment (CTF) either in a homogeneric heterodimerization, or with another family member through heterogeneric heterodimerization. Autocatalytic cleavage is thought to be critical for the maturation, stability, trafficking, and function. {ECO:0000305|PubMed:25713288}.

Similarity: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. {ECO:0000305}.

Sequence caution: Sequence=AAN46670.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAD18748.1; Type=Erroneous initiation; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking). {ECO:0000250\|UniProtKB:Q3V3Z3, ECO:0000305\|PubMed:25713288}.


Subcellular location:		Cell membrane {ECO:0000250\|UniProtKB:Q3V3Z3}; Multi-pass membrane protein {ECO:0000305\|PubMed:25713288}.
Tissue specificity:		Expressed in immune cells. Primarily found in granulocytes. Found in eosinophils. {ECO:0000269\|PubMed:21724806}.
Ptm:		Autoproteolysis between residues Leu-226 and Thr-227 occurs in the lumen of the endoplasmic reticulum during receptor biosynthesis. The N- terminal fragment (NTF) subsequently reassociates with the C-terminal fragment (CTF) either in a homogeneric heterodimerization, or with another family member through heterogeneric heterodimerization. Autocatalytic cleavage is thought to be critical for the maturation, stability, trafficking, and function. {ECO:0000305\|PubMed:25713288}.
Similarity:		Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. {ECO:0000305}.
Sequence caution:		Sequence=AAN46670.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAD18748.1; Type=Erroneous initiation; Evidence={ECO:0000305};