UniProt functional annotation for P14416



	UniProt functional annotation for P14416

UniProt code: P14416.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:21645528). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity). {ECO:0000250|UniProtKB:P61168, ECO:0000269|PubMed:21645528}.

Subunit: Forms homo- and heterooligomers with DRD4 (PubMed:21184734). The interaction with DRD4 may modulate agonist-induced downstream signaling (PubMed:21184734). Interacts with CADPS and CADPS2 (PubMed:15857609). Interacts with GPRASP1, PPP1R9B and CLIC6 (By similarity). Interacts with ARRB2 (By similarity). Interacts with HTR2A (PubMed:21645528). Interacts with GNAI2 isoform sGi2, the interaction allows the creation of an intracellular pool of DRD2 that can be released to cell surface upon agonist stimulation (PubMed:17550964). Interacts with DRD1 (By similarity). Interacts with KCNA2 (By similarity). {ECO:0000250|UniProtKB:P61168, ECO:0000250|UniProtKB:P61169}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:21645528, ECO:0000269|PubMed:26535572}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:26535572}; Multi-pass membrane protein {ECO:0000255}.

Tissue specificity: [Isoform 1]: Expressed in the anterior pituitary gland. {ECO:0000269|PubMed:2531656}.

Tissue specificity: [Isoform 2]: Expressed in the anterior pituitary gland. {ECO:0000269|PubMed:2531656}.

Ptm: Palmitoylated. Palmitoylation which is required for proper localization to the plasma membrane and stability of the receptor could be carried on by ZDHHC4, ZDHHC3 and ZDHHC8. {ECO:0000269|PubMed:26535572}.

Polymorphism: Genetic variations in DRD2 may determine the genetic susceptibility to alcoholism [MIM:103780]. Genetic variations in DRD2 might be a protective factor against the development of withdrawal symptoms but might also be a risk factor in a highly burdened subgroup of alcoholics with a paternal and grandpaternal history of alcoholism and might contribute to suicide risk in alcoholics. {ECO:0000305|PubMed:15389757}.

Similarity: Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:21645528). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity). {ECO:0000250\|UniProtKB:P61168, ECO:0000269\|PubMed:21645528}.


Subunit:		Forms homo- and heterooligomers with DRD4 (PubMed:21184734). The interaction with DRD4 may modulate agonist-induced downstream signaling (PubMed:21184734). Interacts with CADPS and CADPS2 (PubMed:15857609). Interacts with GPRASP1, PPP1R9B and CLIC6 (By similarity). Interacts with ARRB2 (By similarity). Interacts with HTR2A (PubMed:21645528). Interacts with GNAI2 isoform sGi2, the interaction allows the creation of an intracellular pool of DRD2 that can be released to cell surface upon agonist stimulation (PubMed:17550964). Interacts with DRD1 (By similarity). Interacts with KCNA2 (By similarity). {ECO:0000250\|UniProtKB:P61168, ECO:0000250\|UniProtKB:P61169}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:21645528, ECO:0000269\|PubMed:26535572}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269\|PubMed:26535572}; Multi-pass membrane protein {ECO:0000255}.
Tissue specificity:		[Isoform 1]: Expressed in the anterior pituitary gland. {ECO:0000269\|PubMed:2531656}.
Tissue specificity:		[Isoform 2]: Expressed in the anterior pituitary gland. {ECO:0000269\|PubMed:2531656}.
Ptm:		Palmitoylated. Palmitoylation which is required for proper localization to the plasma membrane and stability of the receptor could be carried on by ZDHHC4, ZDHHC3 and ZDHHC8. {ECO:0000269\|PubMed:26535572}.
Polymorphism:		Genetic variations in DRD2 may determine the genetic susceptibility to alcoholism [MIM:103780]. Genetic variations in DRD2 might be a protective factor against the development of withdrawal symptoms but might also be a risk factor in a highly burdened subgroup of alcoholics with a paternal and grandpaternal history of alcoholism and might contribute to suicide risk in alcoholics. {ECO:0000305\|PubMed:15389757}.
Similarity:		Belongs to the G-protein coupled receptor 1 family. {ECO:0000255\|PROSITE-ProRule:PRU00521}.