|
|
||
|
|
|
|
|
UniProt functional annotation for Q86Y34 | ||
|
|
|
|
|
|
||
| UniProt code: Q86Y34. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42 (PubMed:24178298). Regulates B-cell development (By similarity). Seems to signal through G-alpha(q)-proteins (PubMed:22575658). {ECO:0000250|UniProtKB:Q8R0T6, ECO:0000269|PubMed:22575658, ECO:0000269|PubMed:24178298}. |
|
||
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:22575658}; Multi-pass membrane protein {ECO:0000255}. |
| Tissue specificity: | |
Expressed in cultured primary dermal lymphatic endothelial cells. {ECO:0000269|PubMed:24178298}. |
| Similarity: | |
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. {ECO:0000305}. |
| Sequence caution: | |
Sequence=BAD18774.1; Type=Frameshift; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.