PDBsum entry 7d1v

Chaperone/inhibitor

PDB id: 7d1v

Contents

Protein chain

209 a.a.

Ligands

GOU ×2

Waters ×419

PDB id:

7d1v

Name:

Chaperone/inhibitor

Title:

Hsp90 alpha n-terminal domain in complex with a 6c compund

Structure:

Heat shock protein hsp 90-alpha. Chain: a. Synonym: heat shock 86 kda,hsp86,tumor-specific transplantation 86 kda antigen,tsta. Engineered: yes

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Gene: hsp90aa1, hsp86, hsp86-1, hspca. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.33Å R-factor: 0.179 R-free: 0.194

Authors:

S.C.Shin,E.E.Kim

Key ref:

S.C.Shin et al. (2020). Structural basis for design of new purine-Based inhib targeting the hydrophobic binding pocket of hsp90.. Int j mol sci, 21, . PubMed id: 33317068 DOI: 10.3390/IJMS21249377

Date:

15-Sep-20 Release date: 28-Jul-21

Protein chain

P07901  (HS90A_MOUSE) -  Heat shock protein HSP 90-alpha from Mus musculus

Seq: 733 a.a.

Struc: 209 a.a.

Enzyme reactions

• Enzyme class: E.C.3.6.4.10 - non-chaperonin molecular chaperone ATPase.
• Reaction: ATP + H2O = ADP + phosphate + H⁺

ATP + H2O = ADP (Bound ligand (Het Group name = GOU) matches with 51.61% similarity) + phosphate + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site