PDBsum entry 7d0r

Transferase

PDB id: 7d0r

Contents

Protein chains

274 a.a.

27 a.a.

Ligands

EDO

COO

Metals

_ZN

Waters ×89

PDB id:

7d0r

Name:

Transferase

Title:

Crystal structure of human hbo1-brpf2 in complex with crotonoyl- coenzyme a

Structure:

Histone acetyltransferase kat7. Chain: a. Synonym: histone acetyltransferase binding to orc1,lysine acetyltransferase 7,moz,ybf2/sas3,sas2 and tip60 protein 2,myst-2. Engineered: yes. Brd1 protein. Chain: b. Synonym: brpf2. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: kat7, hbo1, hboa, myst2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: brd1. Expression_system_taxid: 562

Resolution:

1.95Å R-factor: 0.185 R-free: 0.231

Authors:

W.Li,J.Ding

Key ref:

Y.Xiao et al. (2021). Hbo1 is a versatile histone acyltransferase critical promoter histone acylations.. Nucleic acids res, 49, 8037. PubMed id: 34259319

Date:

11-Sep-20 Release date: 07-Jul-21

Protein chain

O95251  (KAT7_HUMAN) -  Histone acetyltransferase KAT7 from Homo sapiens

Seq: 611 a.a.

Struc: 274 a.a.*

Protein chain

O95696  (BRD1_HUMAN) -  Bromodomain-containing protein 1 from Homo sapiens

Seq: 1058 a.a.

Struc: 27 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.2.3.1.48 - histone acetyltransferase.
• Reaction: L-lysyl-[protein] + acetyl-CoA = N₆-acetyl-L-lysyl-[protein] + CoA + H⁺

L-lysyl-[protein] (Bound ligand (Het Group name = COO) matches with 96.23% similarity) + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site