|
|
||
|
|
|
|
|
UniProt functional annotation for Q3U5C8 | ||
|
|
|
|
|
|
||
| UniProt code: Q3U5C8. |
|
||
| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
|
||
|
||
| Function: | |
Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 (By similarity). {ECO:0000250}. |
|
||
| Subunit: | |
Interacts with ELMO2, EPHA2, RAC1 and RHOG; mediates activation of RAC1 by EPHA2. Interacts with TAX1BP3 (via PDZ domain) (By similarity). {ECO:0000250}. |
| Subcellular location: | |
Cytoplasm {ECO:0000250}. |
| Domain: | |
The PDZ-binding motif mediates interaction with TAX1BP3. |
| Sequence caution: | |
Sequence=BAE32151.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.