UniProt functional annotation for P62152



	UniProt functional annotation for P62152

UniProt code: P62152.

Organism: Drosophila melanogaster (Fruit fly).

Taxonomy: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.

Function: Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) (By similarity). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). In photoreceptor cells, light-induced Ca(2+) influx activates calmodulin, which in turn is likely to promote Crag activity in trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes (PubMed:23226104). Together with Akap200, regulates PKA activity and ethanol-induced sensitivity and tolerance (PubMed:10480937, PubMed:29444420). {ECO:0000250|UniProtKB:P02599, ECO:0000269|PubMed:10480937, ECO:0000269|PubMed:23226104, ECO:0000269|PubMed:29444420}.

Subunit: Interacts with Crag (PubMed:18331716). Interacts with stac (PubMed:9813038). Interacts with Akap200; the interaction is calcium- dependent and is inhibited by PKC-mediated phosphorylation of Akap200 (PubMed:10480937). {ECO:0000269|PubMed:10480937, ECO:0000269|PubMed:18331716, ECO:0000269|PubMed:9813038}.

Subcellular location: Cytoplasm, cell cortex {ECO:0000269|PubMed:18331716}.

Ptm: Trimethylation of Lys-116 observed in other calmodulins is absent here, but does occur at Lys-95 specifically in the compound eye.

Disruption phenotype: RNAi-mediated knockdown in the perineurial glia increases ethanol sedation resistance and decreases ethanol tolerance. {ECO:0000269|PubMed:29444420}.

Miscellaneous: This protein has four functional calcium-binding sites.

Miscellaneous: Two alternative gene models exist that generate identical translations.

Similarity: Belongs to the calmodulin family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Drosophila melanogaster (Fruit fly).
Taxonomy:		Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.



Function:		Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) (By similarity). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). In photoreceptor cells, light-induced Ca(2+) influx activates calmodulin, which in turn is likely to promote Crag activity in trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes (PubMed:23226104). Together with Akap200, regulates PKA activity and ethanol-induced sensitivity and tolerance (PubMed:10480937, PubMed:29444420). {ECO:0000250\|UniProtKB:P02599, ECO:0000269\|PubMed:10480937, ECO:0000269\|PubMed:23226104, ECO:0000269\|PubMed:29444420}.


Subunit:		Interacts with Crag (PubMed:18331716). Interacts with stac (PubMed:9813038). Interacts with Akap200; the interaction is calcium- dependent and is inhibited by PKC-mediated phosphorylation of Akap200 (PubMed:10480937). {ECO:0000269\|PubMed:10480937, ECO:0000269\|PubMed:18331716, ECO:0000269\|PubMed:9813038}.
Subcellular location:		Cytoplasm, cell cortex {ECO:0000269\|PubMed:18331716}.
Ptm:		Trimethylation of Lys-116 observed in other calmodulins is absent here, but does occur at Lys-95 specifically in the compound eye.
Disruption phenotype:		RNAi-mediated knockdown in the perineurial glia increases ethanol sedation resistance and decreases ethanol tolerance. {ECO:0000269\|PubMed:29444420}.
Miscellaneous:		This protein has four functional calcium-binding sites.
Miscellaneous:		Two alternative gene models exist that generate identical translations.
Similarity:		Belongs to the calmodulin family. {ECO:0000305}.