UniProt functional annotation for P19334



	UniProt functional annotation for P19334

UniProt code: P19334.

Organism: Drosophila melanogaster (Fruit fly).

Taxonomy: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.

Function: A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Ca(2+) influx may then feed back and inhibit PLC, thereby facilitating phosphatidylinositol 4,5 bisphosphate (PIP2) recycling. Trp and trpl act together in the light response, though it is unclear whether as heteromultimers or as distinct units, and are activated by fatty acids and metabolic stress. Also required for olfactory adaptation and may be involved in olfactory system development. {ECO:0000269|PubMed:10366618, ECO:0000269|PubMed:10908615, ECO:0000269|PubMed:2482778, ECO:0000269|PubMed:2516726, ECO:0000269|PubMed:9930700}.

Subunit: The C-terminus interacts with a PDZ domain of inaD to form the core of the inaD signaling complex. Other members of the complex include norpA (PLC), inaC (PKC), and possibly trpl, ninaC, Fkbp59, calmodulin and rhodopsin. Forms homomultimers and heteromultimers with trpl. Interaction with trpl is mediated in part by the N-terminal region and the transmembrane domains. Also interacts, though to a lower extent, with Trpgamma. {ECO:0000269|PubMed:10896160, ECO:0000269|PubMed:10995445, ECO:0000269|PubMed:9010208, ECO:0000269|PubMed:9215637}.

Subcellular location: Cell membrane {ECO:0000305|PubMed:10995445, ECO:0000305|PubMed:2516726, ECO:0000305|PubMed:7751943, ECO:0000305|PubMed:9010208}; Multi-pass membrane protein {ECO:0000305|PubMed:10995445, ECO:0000305|PubMed:2516726, ECO:0000305|PubMed:7751943, ECO:0000305|PubMed:9010208}. Note=Localized on plasma membrane loops found at the base of the rhabdomere, in close proximity to the calcium stores.

Tissue specificity: Expressed predominantly in the rhabdomeres of photoreceptor cells. Expressed in the third antennal segment and in the olfactory segment at approximately 70 hours after puparium formation during antennal development. {ECO:0000269|PubMed:10366618, ECO:0000269|PubMed:10632594, ECO:0000269|PubMed:10995445, ECO:0000269|PubMed:2516726}.

Ptm: Phosphorylated by inaC. {ECO:0000269|PubMed:10766855}.

Similarity: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. {ECO:0000305}.

Sequence caution: Sequence=AAQ22416.1; Type=Frameshift; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Drosophila melanogaster (Fruit fly).
Taxonomy:		Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.



Function:		A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Ca(2+) influx may then feed back and inhibit PLC, thereby facilitating phosphatidylinositol 4,5 bisphosphate (PIP2) recycling. Trp and trpl act together in the light response, though it is unclear whether as heteromultimers or as distinct units, and are activated by fatty acids and metabolic stress. Also required for olfactory adaptation and may be involved in olfactory system development. {ECO:0000269\|PubMed:10366618, ECO:0000269\|PubMed:10908615, ECO:0000269\|PubMed:2482778, ECO:0000269\|PubMed:2516726, ECO:0000269\|PubMed:9930700}.


Subunit:		The C-terminus interacts with a PDZ domain of inaD to form the core of the inaD signaling complex. Other members of the complex include norpA (PLC), inaC (PKC), and possibly trpl, ninaC, Fkbp59, calmodulin and rhodopsin. Forms homomultimers and heteromultimers with trpl. Interaction with trpl is mediated in part by the N-terminal region and the transmembrane domains. Also interacts, though to a lower extent, with Trpgamma. {ECO:0000269\|PubMed:10896160, ECO:0000269\|PubMed:10995445, ECO:0000269\|PubMed:9010208, ECO:0000269\|PubMed:9215637}.
Subcellular location:		Cell membrane {ECO:0000305\|PubMed:10995445, ECO:0000305\|PubMed:2516726, ECO:0000305\|PubMed:7751943, ECO:0000305\|PubMed:9010208}; Multi-pass membrane protein {ECO:0000305\|PubMed:10995445, ECO:0000305\|PubMed:2516726, ECO:0000305\|PubMed:7751943, ECO:0000305\|PubMed:9010208}. Note=Localized on plasma membrane loops found at the base of the rhabdomere, in close proximity to the calcium stores.
Tissue specificity:		Expressed predominantly in the rhabdomeres of photoreceptor cells. Expressed in the third antennal segment and in the olfactory segment at approximately 70 hours after puparium formation during antennal development. {ECO:0000269\|PubMed:10366618, ECO:0000269\|PubMed:10632594, ECO:0000269\|PubMed:10995445, ECO:0000269\|PubMed:2516726}.
Ptm:		Phosphorylated by inaC. {ECO:0000269\|PubMed:10766855}.
Similarity:		Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. {ECO:0000305}.
Sequence caution:		Sequence=AAQ22416.1; Type=Frameshift; Evidence={ECO:0000305};