UniProt functional annotation for Q8R3R8



	UniProt functional annotation for Q8R3R8

UniProt code: Q8R3R8.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover. {ECO:0000250|UniProtKB:Q9H0R8}.

Subunit: Interacts with ATG13, OPRK1, RB1CC1 and ULK1 (By similarity). Interacts with TP53INP1 and TP53INP2 (By similarity). Directly interacts with SQSTM1 (By similarity). Interacts with ATG3, ATG7 and MAP15 (PubMed:16704426). Interacts with TECPR2 (By similarity). Interacts with TBC1D5 (By similarity). Interacts with MAPK15 (By similarity). Interacts with TRIM5 (By similarity). Interacts with MEFV and TRIM21 (By similarity). Interacts with WDFY3 (By similarity). Interacts with the reticulophagy receptor TEX264 (By similarity). Interacts with UBA5 (By similarity). Interacts with KBTBD6 AND KBTBD7; the interaction is direct (By similarity). {ECO:0000250|UniProtKB:Q9H0R8, ECO:0000269|PubMed:16704426}.

Subcellular location: Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q9H0R8}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9H0R8}; Lipid-anchor {ECO:0000250|UniProtKB:Q9H0R8}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q0VGK0}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q0VGK0}. Golgi apparatus {ECO:0000250|UniProtKB:Q0VGK0}.

Tissue specificity: Expressed in testis and heart at high levels. {ECO:0000269|PubMed:11414770}.

Ptm: The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL1-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL1-II (By similarity). ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes (PubMed:14530254, PubMed:16704426). {ECO:0000250|UniProtKB:Q9H0R8, ECO:0000269|PubMed:14530254, ECO:0000269|PubMed:16704426}.

Similarity: Belongs to the ATG8 family. {ECO:0000305}.

Sequence caution: Sequence=BAE39576.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover. {ECO:0000250\|UniProtKB:Q9H0R8}.


Subunit:		Interacts with ATG13, OPRK1, RB1CC1 and ULK1 (By similarity). Interacts with TP53INP1 and TP53INP2 (By similarity). Directly interacts with SQSTM1 (By similarity). Interacts with ATG3, ATG7 and MAP15 (PubMed:16704426). Interacts with TECPR2 (By similarity). Interacts with TBC1D5 (By similarity). Interacts with MAPK15 (By similarity). Interacts with TRIM5 (By similarity). Interacts with MEFV and TRIM21 (By similarity). Interacts with WDFY3 (By similarity). Interacts with the reticulophagy receptor TEX264 (By similarity). Interacts with UBA5 (By similarity). Interacts with KBTBD6 AND KBTBD7; the interaction is direct (By similarity). {ECO:0000250\|UniProtKB:Q9H0R8, ECO:0000269\|PubMed:16704426}.
Subcellular location:		Cytoplasmic vesicle, autophagosome {ECO:0000250\|UniProtKB:Q9H0R8}. Cytoplasmic vesicle membrane {ECO:0000250\|UniProtKB:Q9H0R8}; Lipid-anchor {ECO:0000250\|UniProtKB:Q9H0R8}. Cytoplasm, cytoskeleton {ECO:0000250\|UniProtKB:Q0VGK0}. Endoplasmic reticulum {ECO:0000250\|UniProtKB:Q0VGK0}. Golgi apparatus {ECO:0000250\|UniProtKB:Q0VGK0}.
Tissue specificity:		Expressed in testis and heart at high levels. {ECO:0000269\|PubMed:11414770}.
Ptm:		The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL1-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL1-II (By similarity). ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes (PubMed:14530254, PubMed:16704426). {ECO:0000250\|UniProtKB:Q9H0R8, ECO:0000269\|PubMed:14530254, ECO:0000269\|PubMed:16704426}.
Similarity:		Belongs to the ATG8 family. {ECO:0000305}.
Sequence caution:		Sequence=BAE39576.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};