PDBsum entry 7c2e

Membrane protein

PDB id: 7c2e

Contents

Protein chains

193 a.a.

338 a.a.

57 a.a.

126 a.a.

380 a.a.

Ligands

FFR

PDB id:

7c2e

Name:

Membrane protein

Title:

Glp-1r-gs complex structure with a small molecule full agonist

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes.

Source:

Homo sapiens. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Human. Gene: gnb1. Gene: gng2. Lama glama. Organism_taxid: 9844.

Authors:

H.Ma,D.P.Yuan,W.Huang,Z.Wenge,E.Xu

Key ref:

H.Ma et al. (2020). Structural insights into the activation of GLP-1R by a small molecule agonist. Cell Res, 30, 1140-1142. PubMed id: 32724086 DOI: 10.1038/s41422-020-0384-8

Date:

07-May-20 Release date: 26-Aug-20

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 193 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 126 a.a.

Protein chain

P43220  (GLP1R_HUMAN) -  Glucagon-like peptide 1 receptor from Homo sapiens

Seq: 463 a.a.

Struc: 380 a.a.*

* PDB and UniProt seqs differ at 40 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????

DOI no: 10.1038/s41422-020-0384-8

Cell Res 30:1140-1142 (2020)

PubMed id: 32724086

Structural insights into the activation of GLP-1R by a small molecule agonist.

H.Ma, W.Huang, X.Wang, L.Zhao, Y.Jiang, F.Liu, W.Guo, X.Sun, W.Zhong, D.Yuan, H.E.Xu.

ABSTRACT

No abstract given.