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UniProt functional annotation for Q8TDU6 | ||
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| UniProt code: Q8TDU6. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. {ECO:0000269|PubMed:12419312, ECO:0000269|PubMed:12524422}. |
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| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:12524422}; Multi-pass membrane protein {ECO:0000269|PubMed:12524422}. |
| Tissue specificity: | |
Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum. {ECO:0000269|PubMed:12044878, ECO:0000269|PubMed:12419312, ECO:0000269|PubMed:12524422}. |
| Similarity: | |
Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}. |
Annotations taken from UniProtKB at the EBI.