|
|
||
|
|
|
|
|
UniProt functional annotation for P69506 | ||
|
|
|
|
|
|
||
| UniProt code: P69506. |
|
||
| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
|
||
|
||
| Function: | |
Di-iron-containing protein involved in the repair of iron- sulfur clusters damaged by oxidative and nitrosative stress conditions. {ECO:0000269|PubMed:16553864, ECO:0000269|PubMed:17289666, ECO:0000269|PubMed:18357473}. |
|
||
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:18357473}. |
| Subcellular location: | |
Cytoplasm {ECO:0000305}. |
| Induction: | |
Induced by nitric oxide. Negatively regulated by Fnr and Fur, but no obvious Fnr or Fur binding sites were found, suggesting that this regulation could be indirect. {ECO:0000269|PubMed:15546870, ECO:0000269|PubMed:16553864}. |
| Disruption phenotype: | |
Mutants show a severe growth impairment under nitrosative and oxidative stress conditions. Mutation increases the sensitivity of the bacterium to iron starvation, increases the intracellular levels of free iron, and decreases the activity of several iron-sulfur-containing proteins. {ECO:0000269|PubMed:15546870, ECO:0000269|PubMed:16553864, ECO:0000269|PubMed:17289666}. |
| Similarity: | |
Belongs to the RIC family. YtfE subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.