PDBsum entry 7bb7

Membrane protein

PDB id: 7bb7

Contents

Protein chains

268 a.a.

339 a.a.

218 a.a.

60 a.a.

128 a.a.

Ligands

CYS-TYR-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2

PDB id:

7bb7

Name:

Membrane protein

Title:

Avp-v2r-galphas-beta1-gamma2-nb35(t state)

Structure:

Vasopressin v2 receptor. Chain: a. Synonym: v2r,avpr v2,antidiuretic hormone receptor,renal-type arginine vasopressin receptor. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: c. Synonym: transducin beta chain 1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: avpr2, adhr, dir, dir3, v2r. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: gnb1. Gene: gnas, gnas1, gsp.

Authors:

J.Bous,B.Mouillac,P.Bron,S.Granier,N.Floquet,C.Leyrat

Key ref:

J.Bous et al. (2021). Cryo-Electron microscopy structure of the antidiureti hormone arginine-Vasopressin V2 receptor signaling co. Sci adv, 7, . PubMed id: 34020960

Date:

17-Dec-20 Release date: 02-Jun-21

Protein chain

P30518  (V2R_HUMAN) -  Vasopressin V2 receptor from Homo sapiens

Seq: 371 a.a.

Struc: 268 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 218 a.a.*

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 60 a.a.

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

* PDB and UniProt seqs differ at 34 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain E: E.C.3.6.5.- - ?????