PDBsum entry 7zl9

Membrane protein

PDB id: 7zl9

Contents

Protein chain

398 a.a.

Ligands

OLA ×5

OLC

PEG

UNX ×5

Waters ×3

PDB id:

7zl9

Name:

Membrane protein

Title:

Crystal structure of human gpcr niacin receptor (hca2)

Structure:

Hydroxycarboxylic acid receptor 2,soluble cytochrome b562. Chain: a. Synonym: g-protein coupled receptor 109a,g-protein coupled receptor hm74a,niacin receptor 1,nicotinic acid receptor,cytochrome b-562. Engineered: yes

Source:

Homo sapiens, escherichia coli. Human. Organism_taxid: 9606, 562. Gene: hcar2, gpr109a, hca2, hm74a, niacr1, cybc. Expressed in: homo sapiens. Expression_system_taxid: 9606

Resolution:

2.70Å R-factor: 0.229 R-free: 0.248

Authors:

Y.Yang,H.J.Kang,R.G.Gao,J.J.Wang,G.W.Han,J.F.Fiberto,L.J.Wu,J.H.Tong, L.Qu,Y.R.Wu,R.Pileski,X.M.Li,X.C.Zhang,S.W.Zhao,T.Kenakin,Q.Wang, R.C.Stevens,W.Peng,B.L.Roth,Z.H.Rao,Z.J.Liu

Key ref:

Y.Yang et al. (2023). Structural insights into the human niacin receptor hc signalling complex.. Nat commun, 14, 1692. PubMed id: 36973264

Date:

14-Apr-22 Release date: 12-Apr-23

Protein chain

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 398 a.a.*

Protein chain

Q8TDS4  (HCAR2_HUMAN) -  Hydroxycarboxylic acid receptor 2 from Homo sapiens

Seq: 363 a.a.

Struc: 398 a.a.*

* PDB and UniProt seqs differ at 73 residue positions (black crosses)