PDBsum entry 7yk6

Structural protein

PDB id: 7yk6

Contents

Protein chains

55 a.a.

211 a.a.

284 a.a.

230 a.a.

338 a.a.

Ligands

IYF

PDB id:

7yk6

Name:

Structural protein

Title:

Cryo-em structure of the compound 4-bound human relaxin family peptide receptor 4 (rxfp4)-gi complex

Structure:

Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2. Chain: g. Synonym: g gamma-i. Engineered: yes. Guanine nucleotide-binding protein g(i) subunit alpha-2. Chain: i. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes.

Source:

Bos taurus. Cattle. Organism_taxid: 9913. Gene: gng2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens. Human. Organism_taxid: 9606.

Authors:

Y.Chen,Q.T.Zhou,J.Wang,Y.W.Xu,Y.Wang,J.H.Yan,Y.B.Wang,Q.Zhu,F.H.Zhao, C.H.Li,C.W.Chen,X.Q.Cai,R.A.D.Bathgate,C.Shen,H.Liu,H.E.Xu,D.H.Yang, M.W.Wang

Key ref:

Y.Chen et al. (2023). Ligand recognition mechanism of the human relaxin fam peptide receptor 4 (rxfp4).. Nat commun, 14, 492. PubMed id: 36717591

Date:

21-Jul-22 Release date: 01-Mar-23

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 55 a.a.

Protein chain

P04899  (GNAI2_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-2 from Homo sapiens

Seq: 355 a.a.

Struc: 211 a.a.*

Protein chain

Q8TDU9  (RL3R2_HUMAN) -  Relaxin-3 receptor 2 from Homo sapiens

Seq: 374 a.a.

Struc: 284 a.a.

Protein chain

No UniProt id for this chain

Struc: 230 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

* PDB and UniProt seqs differ at 47 residue positions (black crosses)