PDBsum entry 7yac

Signaling protein

PDB id: 7yac

Contents

Protein chains

226 a.a.

340 a.a.

61 a.a.

281 a.a.

232 a.a.

Ligands

IUD

PDB id:

7yac

Name:

Signaling protein

Title:

Paltusotine-bound sstr2-gi complex

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes. Mutation: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Gene: sstr2.

Authors:

J.Zhao,Z.Shao

Key ref:

J.Zhao et al. (2023). Prospect of acromegaly therapy: molecular mechanism o clinical drugs octreotide and paltusotine.. Nat commun, 14, 962. PubMed id: 36810324

Date:

27-Jun-22 Release date: 19-Apr-23

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 226 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 340 a.a.*

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 61 a.a.

Protein chain

P30874  (SSR2_HUMAN) -  Somatostatin receptor type 2 from Homo sapiens

Seq: 369 a.a.

Struc: 281 a.a.

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

* PDB and UniProt seqs differ at 5 residue positions (black crosses)