PDBsum entry 7y24

Structural protein

PDB id: 7y24

Contents

Protein chains

212 a.a.

338 a.a.

56 a.a.

231 a.a.

284 a.a.

Ligands

DPN-CYS-PHE-DTR-LYS-THR-CYS-THR

PDB id:

7y24

Name:

Structural protein

Title:

Cryo-em structure of the octreotide-bound sstr2-minigo-scfv16 complex

Structure:

Guanine nucleotide-binding protein g(o) subunit alpha. Chain: a. Fragment: unp residues 5-57, unp residues 182-231, unp residues 242- 354. Engineered: yes. Mutation: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnao1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Gene: gnb1. Expressed in: spodoptera frugiperda.

Authors:

S.Chen,S.Zheng

Key ref:

S.Chen et al. (2023). Molecular basis for the selective g protein signaling somatostatin receptors.. Nat chem biol, 19, 133. PubMed id: 36138141

Date:

09-Jun-22 Release date: 19-Oct-22

Protein chain

P09471  (GNAO_HUMAN) -  Guanine nucleotide-binding protein G(o) subunit alpha from Homo sapiens

Seq: 354 a.a.

Struc: 212 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 56 a.a.

Protein chain

No UniProt id for this chain

Struc: 231 a.a.

Protein chain

P30874  (SSR2_HUMAN) -  Somatostatin receptor type 2 from Homo sapiens

Seq: 369 a.a.

Struc: 284 a.a.

* PDB and UniProt seqs differ at 7 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????