PDBsum entry 7y12

Signaling protein

PDB id: 7y12

Contents

Protein chains

218 a.a.

338 a.a.

57 a.a.

264 a.a.

232 a.a.

Ligands

BAL

PLM ×3

PDB id:

7y12

Name:

Signaling protein

Title:

Cryo-em structure of mrgd-gi complex with beta-alanine

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes. Mutation: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Mus musculus. House mouse. Organism_taxid: 10090.

Authors:

S.Suzuki,M.Iida,A.Kawamoto,A.Oshima

Key ref:

S.Suzuki et al. Structural insight into the activation mechanism of m with heterotrimeric gi-Protein. To be published, . PubMed id: 35840655

Date:

06-Jun-22 Release date: 20-Jul-22

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 218 a.a.*

Protein chain

P62874  (GBB1_MOUSE) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Mus musculus

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P63213  (GBG2_MOUSE) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Mus musculus

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 264 a.a.*

Protein chain

Q8TDS7  (MRGRD_HUMAN) -  Mas-related G-protein coupled receptor member D from Homo sapiens

Seq: 321 a.a.

Struc: 264 a.a.

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

* PDB and UniProt seqs differ at 68 residue positions (black crosses)