PDBsum entry 7xw9

Structural protein

PDB id: 7xw9

Contents

Protein chains

288 a.a.

227 a.a.

338 a.a.

56 a.a.

231 a.a.

Ligands

PCA-HIS-PRO-NH2

PDB id:

7xw9

Name:

Structural protein

Title:

Cryo-em structure of the trh-bound human trhr-gq complex

Structure:

Thyrotropin-releasing hormone receptor. Chain: r. Synonym: trh-r,thyroliberin receptor. Engineered: yes. Guanine nucleotide-binding protein g(q) subunit alpha. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: trhr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Rattus norvegicus. Norway rat. Organism_taxid: 10116.

Authors:

S.Ji,Y.Dong,L.Chen,S.Zang,D.Shen,J.Guo,J.Qin,H.Zhang,W.Wang,Q.Shen, C.Mao,Y.Zhang

Key ref:

S.Y.Ji et al. (2022). Molecular basis for the activation of thyrotropin-Rel hormone receptor.. Cell discov, 8, 116. PubMed id: 36280665

Date:

26-May-22 Release date: 28-Dec-22

Protein chain

P34981  (TRFR_HUMAN) -  Thyrotropin-releasing hormone receptor from Homo sapiens

Seq: 398 a.a.

Struc: 288 a.a.

Protein chain

No UniProt id for this chain

Struc: 227 a.a.

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 56 a.a.

Protein chain

No UniProt id for this chain

Struc: 231 a.a.