PDBsum entry 7xmr

Signaling protein

PDB id: 7xmr

Contents

Protein chains

285 a.a.

224 a.a.

314 a.a.

34 a.a.

14 a.a.

PDB id:

7xmr

Name:

Signaling protein

Title:

Cryoem structure of the somatostatin receptor 2 (sstr2) in complex with gi1 and its endogeneous peptide ligand sst-14

Structure:

Somatostatin receptor type 2. Chain: r. Synonym: ss-2-r,ss2-r,ss2r,srif-1. Engineered: yes. Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: sstr2. Expressed in: insecta environmental sample. Expression_system_taxid: 2588572. Gene: gnai1. Gene: gnb1. Gene: gng2.

Authors:

Z.Wenli,H.Shuo,Q.Na,Z.Wenbo,L.Mengjie,Y.Dehua,W.Ming-Wei,B.Wu,Q.Zhao

Key ref:

W.Zhao et al. Structural insights into ligand recognition and selec of somatostatin receptors.. Cell res, . PubMed id: 35739238

Date:

26-Apr-22 Release date: 03-Aug-22

Protein chain

P30874  (SSR2_HUMAN) -  Somatostatin receptor type 2 from Homo sapiens

Seq: 369 a.a.

Struc: 285 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 224 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 314 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 34 a.a.

Protein chain

P61278  (SMS_HUMAN) -  Somatostatin from Homo sapiens

Seq: 116 a.a.

Struc: 14 a.a.

* PDB and UniProt seqs differ at 5 residue positions (black crosses)