PDBsum entry 7x8r

Membrane protein

PDB id: 7x8r

Contents

Protein chains

234 a.a.

338 a.a.

55 a.a.

126 a.a.

298 a.a.

Ligands

BYI

PDB id:

7x8r

Name:

Membrane protein

Title:

Cryo-em structure of the boc5-bound hglp-1r-gs complex

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1.

Source:

Bos taurus. Cattle. Organism_taxid: 9913. Gene: gnas, gnas1, gsp. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Rattus norvegicus. Norway rat. Organism_taxid: 10116.

Authors:

Z.T.Cong,Q.T.Zhou,Y.Li,L.N.Chen,Z.C.Zhang,A.Y.Liang,Q.Liu,X.Y.Wu, A.T.Dai,T.Xia,W.Wu,Y.Zhang,D.H.Yang,M.W.Wang

Key ref:

Z.Cong et al. (2022). Structural basis of peptidomimetic agonism revealed b small- Molecule glp-1r agonists boc5 and wb4-24.. Proc natl acad sci usa, 119, 55119. PubMed id: 35561211

Date:

14-Mar-22 Release date: 29-Jun-22

Protein chain

P04896  (GNAS2_BOVIN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Bos taurus

Seq: 394 a.a.

Struc: 234 a.a.*

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 55 a.a.

Protein chain

No UniProt id for this chain

Struc: 126 a.a.

Protein chain

P43220  (GLP1R_HUMAN) -  Glucagon-like peptide 1 receptor from Homo sapiens

Seq: 463 a.a.

Struc: 298 a.a.*

* PDB and UniProt seqs differ at 29 residue positions (black crosses)