PDBsum entry 7wvv

Signaling protein

PDB id: 7wvv

Contents

Protein chains

298 a.a.

223 a.a.

334 a.a.

51 a.a.

Ligands

FME-LEU-PHE-ILE-ILE

PDB id:

7wvv

Name:

Signaling protein

Title:

Cryo-em structure of the human formyl peptide receptor 2 in complex with fmlfii and gi2

Structure:

Fme-leu-phe-ile-ile. Chain: l. Engineered: yes. Soluble cytochrome b562,n-formyl peptide receptor 2. Chain: r. Synonym: cytochrome b-562,fmlp-related receptor i,fmlp-r-i,formyl peptide receptor-like 1,hm63,lipoxin a4 receptor,lxa4 receptor,rfp. Engineered: yes. Mutation: yes.

Source:

Synthetic: yes. Homo sapiens. Organism_taxid: 9606. Human. Gene: cybc, fpr2, fprh1, fprl1, lxa4r. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnai2, gnai2b. Gene: gnb1.

Authors:

Y.Zhu,X.Lin,X.Zong,S.Han,Q.Zhao,B.Wu

Key ref:

Y.Zhu et al. (2022). Structural basis of fpr2 in recognition of a beta 42 neuroprotection by humanin.. Nat commun, 13, 1775. PubMed id: 35365641

Date:

11-Feb-22 Release date: 13-Apr-22

Protein chain

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 298 a.a.*

Protein chain

P25090  (FPR2_HUMAN) -  N-formyl peptide receptor 2 from Homo sapiens

Seq: 351 a.a.

Struc: 298 a.a.*

Protein chain

P04899  (GNAI2_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-2 from Homo sapiens

Seq: 355 a.a.

Struc: 223 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 334 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 51 a.a.

* PDB and UniProt seqs differ at 123 residue positions (black crosses)