PDBsum entry 7wv9

Membrane protein

PDB id: 7wv9

Contents

Protein chains

224 a.a.

338 a.a.

57 a.a.

290 a.a.

232 a.a.

Ligands

9GF

7IC

PDB id:

7wv9

Name:

Membrane protein

Title:

Allosteric modulator zcz011 binding to cp55940-bound cannabinoid receptor 1 in complex with gi protein

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-2. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai2, gnai2b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Gene: cnr1, cnr.

Authors:

Z.Xu,Z.Shao

Key ref:

X.Yang et al. Molecular mechanism of allosteric modulation for the cannabinoid receptor cb1.. Nat chem biol, . PubMed id: 35637350

Date:

10-Feb-22 Release date: 15-Jun-22

Protein chain

P04899  (GNAI2_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-2 from Homo sapiens

Seq: 355 a.a.

Struc: 224 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

P21554  (CNR1_HUMAN) -  Cannabinoid receptor 1 from Homo sapiens

Seq: 472 a.a.

Struc: 290 a.a.

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

* PDB and UniProt seqs differ at 4 residue positions (black crosses)