PDBsum entry 7wic

Structural protein

PDB id: 7wic

Contents

Protein chains

14 a.a.

288 a.a.

225 a.a.

339 a.a.

58 a.a.

234 a.a.

PDB id:

7wic

Name:

Structural protein

Title:

Cryo-em structure of the ss-14-bound human sstr2-gi1 complex

Structure:

Somatostatin-14. Chain: l. Engineered: yes. Somatostatin receptor type 2. Chain: r. Synonym: ss-2-r,ss2-r,ss2r,srif-1. Engineered: yes. Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a.

Source:

Synthetic: yes. Homo sapiens. Organism_taxid: 9606. Human. Gene: sstr2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnai1. Rattus norvegicus.

Authors:

L.Chen,W.Wang,Y.Dong,D.Shen,J.Guo,J.Qin,H.Zhang,Q.Shen,Y.Zhang,C.Mao

Key ref:

L.N.Chen et al. Structures of the endogenous peptide- And selective non-Peptide agonist-Bound sstr2 signaling complexes.. Cell res, . PubMed id: 35578016

Date:

03-Jan-22 Release date: 01-Jun-22

Protein chain

P61278  (SMS_HUMAN) -  Somatostatin from Homo sapiens

Seq: 116 a.a.

Struc: 14 a.a.

Protein chain

P30874  (SSR2_HUMAN) -  Somatostatin receptor type 2 from Homo sapiens

Seq: 369 a.a.

Struc: 288 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 225 a.a.*

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 58 a.a.

Protein chain

No UniProt id for this chain

Struc: 234 a.a.

* PDB and UniProt seqs differ at 4 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????