PDBsum entry 7wc8

Membrane protein

PDB id: 7wc8

Contents

Protein chain

360 a.a.

Ligands

CLR ×4

1PE

OLC ×11

92S

PEG

Metals

_MG

Waters ×8

PDB id:

7wc8

Name:

Membrane protein

Title:

Crystal structure of serotonin 2a receptor in complex with lumateperone

Structure:

5-hydroxytryptamine receptor 2a,5-hydroxytryptamine receptor 2a,soluble cytochrome b562. Chain: a. Synonym: 5-ht-2,5-ht-2a,serotonin receptor 2a. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: htr2a, htr2, htr2a, cybc. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

2.45Å R-factor: 0.220 R-free: 0.244

Authors:

D.Cao,J.Yu,H.Wang,Z.Luo,X.Liu,L.He,J.Qi,L.Fan,L.Tang,Z.Chen,J.Li, J.Cheng,S.Wang

Key ref:

D.Cao et al. Structure-Based discovery of non-Hallucinogenic psych analogs.. Science, . PubMed id: 35084960

Date:

18-Dec-21 Release date: 26-Jan-22

Protein chain

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 360 a.a.*

Protein chain

P28223  (5HT2A_HUMAN) -  5-hydroxytryptamine receptor 2A from Homo sapiens

Seq: 471 a.a.

Struc: 360 a.a.*

* PDB and UniProt seqs differ at 97 residue positions (black crosses)