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PDBsum entry 7v35
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protein ligands Protein-protein interface(s) links
Structural protein PDB id
7v35

 

 

 

 

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Contents
Protein chains
207 a.a.
338 a.a.
49 a.a.
126 a.a.
28 a.a.
392 a.a.
Ligands
D6M
PDB id:
7v35
Name: Structural protein
Title: Cryo-em structure of the gipr/glp-1r/gcgr triagonist peptide 20-bound human gcgr-gs complex
Structure: Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Rattus norvegicus. Rat. Organism_taxid: 10116.
Authors: F.H.Zhao,Q.T.Zhou,Z.T.Cong,K.N.Hang,X.Y.Zou,C.Zhang,Y.Chen,A.T.Dai, A.Y.Liang,Q.Q.Ming,M.Wang,L.N.Chen,P.Y.Xu,R.L.Chang,W.B.Feng,T.Xia, Y.Zhang,B.L.Wu,D.H.Yang,L.H.Zhao,H.E.Xu,M.W.Wang
Key ref: f.h.zhao et al. (2022). Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors. Nat Commun, 13, 1057-1057. PubMed id: 35217653
Date:
10-Aug-21     Release date:   02-Mar-22    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens
Seq:
Struc: 		394 a.a.
207 a.a.*
Protein chain
Pfam   ArchSchema ?
P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus
Seq:
Struc: 		340 a.a.
338 a.a.
Protein chain
Pfam   ArchSchema ?
P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus
Seq:
Struc: 		71 a.a.
49 a.a.
Protein chain
No UniProt id for this chain
Struc: 126 a.a.
Protein chain
No UniProt id for this chain
Struc: 28 a.a.
Protein chain
Pfam   ArchSchema ?
P47871  (GLR_HUMAN) -  Glucagon receptor from Homo sapiens
Seq:
Struc: 		477 a.a.
392 a.a.
Key:    PfamA domain  Secondary structure
* PDB and UniProt seqs differ at 39 residue positions (black crosses)

 

 
Nat Commun 13:1057-1057 (2022)
PubMed id: 35217653  
 
 
Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
f.h.zhao, q.t.zhou, z.t.cong, k.n.hang, x.y.zou, c.zhang, ya.t.dai, a.y.liang, q.q.ming, m.wang, l.n.chen, p.y.xu, r.lw.b.feng, t.xia, y.zhang, b.l.wu, d.h.yang, l.h.zhao, h.e.xm.w.wang.
 
  ABSTRACT  
 
No abstract given.

 

 

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