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PDBsum entry 7ul3
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protein ligands Protein-protein interface(s) links
Membrane protein PDB id
7ul3

 

 

 

 

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Contents
Protein chains
268 a.a.
117 a.a.
183 a.a.
199 a.a.
Ligands
FO9
PDB id:
7ul3
Name: Membrane protein
Title: Cryoem structure of inactive h2r bound to famotidine, nb6m, and nabfab
Structure: Histamine h2 receptor. Chain: a. Synonym: h2r,hh2r,gastric receptor i,kappa-type opioid receptor isoform x1. Engineered: yes. Nanobody 6m. Chain: c. Engineered: yes. Nabfab hc.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hrh2, oprk1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic construct. Organism_taxid: 32630. Expressed in: escherichia coli.
Authors: M.J.Robertson,G.Skiniotis
Key ref: M.J.Robertson et al. Structure determination of inactive-State gpcrs with universal nanobody. To be published, . PubMed id: 36396979
Date:
03-Apr-22     Release date:   29-Jun-22    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P25021  (HRH2_HUMAN) -  Histamine H2 receptor from Homo sapiens
Seq:
Struc: 		359 a.a.
268 a.a.*
Protein chain
Pfam   ArchSchema ?
P41145  (OPRK_HUMAN) -  Kappa-type opioid receptor from Homo sapiens
Seq:
Struc: 		380 a.a.
268 a.a.*
Protein chain
No UniProt id for this chain
Struc: 117 a.a.
Protein chain
No UniProt id for this chain
Struc: 183 a.a.
Protein chain
No UniProt id for this chain
Struc: 199 a.a.
Key:    PfamA domain  Secondary structure
* PDB and UniProt seqs differ at 186 residue positions (black crosses)

 

 

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