PDBsum entry 7tyn

Membrane protein

PDB id: 7tyn

Contents

Protein chains

33 a.a.

373 a.a.

227 a.a.

339 a.a.

55 a.a.

128 a.a.

Ligands

NAG ×2

P42

PLM ×13

Y01

PDB id:

7tyn

Name:

Membrane protein

Title:

Calcitonin receptor in complex with gs and salmon calcitonin peptide

Structure:

Calcitonin-1. Chain: p. Fragment: unp residues 90-121. Synonym: calcitonin-1 precursor,calcitonin-1-like isoform x1. Engineered: yes. Calcitonin receptor. Chain: r. Synonym: ct-r. Engineered: yes.

Source:

Synthetic: yes. Salmo salar. Atlantic salmon. Organism_taxid: 8030. Homo sapiens. Human. Organism_taxid: 9606. Gene: calcr. Expressed in: trichoplusia ni.

Authors:

J.Cao,M.J.Belousoff,R.M.Johnson,D.L.Wootten,P.M.Sexton

Key ref:

J.Cao et al. A structural basis for amylin receptor phenotype. To be published, . PubMed id: 35324283

Date:

13-Feb-22 Release date: 30-Mar-22

Protein chain

B5XGR7  (B5XGR7_SALSA) -  Calcitonin-1 from Salmo salar

Seq: 143 a.a.

Struc: 33 a.a.*

Protein chain

P30988  (CALCR_HUMAN) -  Calcitonin receptor from Homo sapiens

Seq: 474 a.a.

Struc: 373 a.a.

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 227 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 55 a.a.

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

* PDB and UniProt seqs differ at 9 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????