PDBsum entry 7tuz

Immune system

PDB id: 7tuz

Contents

Protein chains

284 a.a.

227 a.a.

339 a.a.

59 a.a.

232 a.a.

Ligands

KJX

PDB id:

7tuz

Name:

Immune system

Title:

Cryo-em structure of 7alpha,25-dihydroxycholesterol-bound ebi2/gpr183 in complex with gi protein

Structure:

G-protein coupled receptor 183. Chain: r. Synonym: epstein-barr virus-induced g-protein coupled receptor 2, ebi2,ebv-induced g-protein coupled receptor 2,hebi2. Engineered: yes. Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gpr183, ebi2. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293 gnti-. Expression_system_atcc_number: crl-3022. Gene: gnai1.

Authors:

H.Chen,W.Hung,X.Li

Key ref:

H.Chen et al. Structures of oxysterol sensor ebi2/gpr183, A key reg of the immune response. To be published, . PubMed id: 35537452

Date:

03-Feb-22 Release date: 13-Apr-22

Protein chain

P32249  (GP183_HUMAN) -  G-protein coupled receptor 183 from Homo sapiens

Seq: 361 a.a.

Struc: 284 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 227 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 59 a.a.

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????