PDBsum entry 7trk

Signaling protein/immune system

PDB id: 7trk

Contents

Protein chains

271 a.a.

338 a.a.

57 a.a.

235 a.a.

225 a.a.

Ligands

IXO

PDB id:

7trk

Name:

Signaling protein/immune system

Title:

Human m4 muscarinic acetylcholine receptor complex with gi1 and the agonist iperoxo

Structure:

Muscarinic acetylcholine receptor m4. Chain: r. Fragment: unp residues 1-241,388-479. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: chrm4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.

Authors:

Z.Vuckovic,J.I.Mobbs,M.J.Belousoff,A.Glukhova,P.M.Sexton,R.Danev, D.M.Thal

Key ref:

D.M.Thal Structural and dynamic mechanisms of allostery at the muscarinic acetylcholine receptor. Elife, .

Date:

29-Jan-22 Release date: 17-May-23

Protein chain

P08173  (ACM4_HUMAN) -  Muscarinic acetylcholine receptor M4 from Homo sapiens

Seq: 479 a.a.

Struc: 271 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 235 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 225 a.a.*

* PDB and UniProt seqs differ at 4 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????