PDBsum entry 7t9i

Membrane protein

PDB id: 7t9i

Contents

Protein chains

86 a.a.

109 a.a.

126 a.a.

596 a.a.

221 a.a.

338 a.a.

56 a.a.

Ligands

NAG-NAG

NAG ×6

PDB id:

7t9i

Name:

Membrane protein

Title:

Native human tsh bound to human thyrotropin receptor in complex with minigs399 (composite structure)

Structure:

Glycoprotein hormones alpha chain. Chain: a. Synonym: anterior pituitary glycoprotein hormones common subunit alpha,choriogonadotropin alpha chain,chorionic gonadotrophin subunit alpha,cg-alpha,follicle-stimulating hormone alpha chain,fsh-alpha, follitropin alpha chain,luteinizing hormone alpha chain,lsh-alpha, lutropin alpha chain,thyroid-stimulating hormone alpha chain,tsh- alpha,thyrotropin alpha chain. Thyrotropin subunit beta.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Lama glama. Organism_taxid: 9844. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: tshr. Expressed in: homo sapiens.

Authors:

B.Faust,Y.Cheng,A.Manglik

Key ref:

B.Faust et al. Autoantibody and hormone activation of the thyrotropi protein-Coupled receptor. To be published, . PubMed id: 35940205

Date:

19-Dec-21 Release date: 03-Aug-22

Protein chain

P01215  (GLHA_HUMAN) -  Glycoprotein hormones alpha chain from Homo sapiens

Seq: 116 a.a.

Struc: 86 a.a.

Protein chain

P01222  (TSHB_HUMAN) -  Thyrotropin subunit beta from Homo sapiens

Seq: 138 a.a.

Struc: 109 a.a.

Protein chain

No UniProt id for this chain

Struc: 126 a.a.

Protein chain

P16473  (TSHR_HUMAN) -  Thyrotropin receptor from Homo sapiens

Seq: 764 a.a.

Struc: 596 a.a.*

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 221 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 56 a.a.

* PDB and UniProt seqs differ at 53 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain X: E.C.3.6.5.- - ?????