PDBsum entry 7t32

Membrane protein

PDB id: 7t32

Contents

Protein chain

375 a.a.

Ligands

ZMA

PDB id:

7t32

Name:

Membrane protein

Title:

Cryoem structure of the adenosine 2a receptor-bril/anti bril fab complex with zm241385

Structure:

Adenosine receptor a2a/soluble cytochrome b562 fusion protein. Chain: a. Synonym: cytochrome b-562. Engineered: yes. Mutation: yes

Source:

Homo sapiens, escherichia coli. Human. Organism_taxid: 9606, 562. Gene: adora2a, adora2, cybc. Expressed in: homo sapiens. Expression_system_taxid: 9606

Authors:

K.H.Zhang,H.Wu,N.Hoppe,A.Manglik,Y.F.Cheng

Key ref:

K.Zhang et al. (2022). Fusion protein strategies for cryo-Em study of g protein-Coupled receptors.. Nat commun, 13, 4366. PubMed id: 35902590

Date:

06-Dec-21 Release date: 10-Aug-22

Protein chain

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 375 a.a.*

Protein chain

P29274  (AA2AR_HUMAN) -  Adenosine receptor A2a from Homo sapiens

Seq: 412 a.a.

Struc: 375 a.a.*

* PDB and UniProt seqs differ at 107 residue positions (black crosses)