PDBsum entry 7sus

Membrane protein

PDB id: 7sus

Contents

Protein chain

347 a.a.

Ligands

8EH

OLC

Metals

_ZN

Waters ×1

PDB id:

7sus

Name:

Membrane protein

Title:

Crystal structure of apelin receptor in complex with small molecule

Structure:

Apelin receptor, with rubredoxin insertion. Chain: a. Engineered: yes. Mutation: yes

Source:

Homo sapiens, clostridium pasteurianum. Human. Organism_taxid: 9606, 1501. Gene: aplnr, agtrl1, apj. Expressed in: trichoplusia ni. Expression_system_taxid: 7111

Resolution:

2.70Å R-factor: 0.253 R-free: 0.274

Authors:

F.Xu,Y.Yue,L.E.Liu,G.W.Han,M.Hanson

Key ref:

Y.Yue et al. (2022). Structural insight into apelin receptor-G protein stoichiometry.. Nat struct mol biol, 29, 688. PubMed id: 35817871

Date:

18-Nov-21 Release date: 27-Jul-22

Protein chain

P00268  (RUBR_CLOPA) -  Rubredoxin from Clostridium pasteurianum

Seq: 54 a.a.

Struc: 347 a.a.

Protein chain

P35414  (APJ_HUMAN) -  Apelin receptor from Homo sapiens

Seq: 380 a.a.

Struc: 347 a.a.*

* PDB and UniProt seqs differ at 63 residue positions (black crosses)