PDBsum entry 7sf8

Membrane protein

PDB id: 7sf8

Contents

Protein chains

257 a.a.

212 a.a.

338 a.a.

53 a.a.

PDB id:

7sf8

Name:

Membrane protein

Title:

Gpr56 (adgrg1) 7tm domain bound to tethered agonist in complex with g protein heterotrimer

Structure:

Isoform 2 of adhesion g-protein coupled receptor g1. Chain: a. Fragment: 7tm domain with activation paptide (unp residues 383-687). Synonym: g-protein coupled receptor 56,protein tm7xn1. Engineered: yes. G protein subunit 13 (gi2-mini-g13 chimera). Chain: b. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: adgrg1, gpr56, tm7ln4, tm7xn1, unq540/pro1083. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Expression_system_taxid: 7108

Authors:

X.Barros-Alvarez,O.Panova,G.Skiniotis

Key ref:

X.Barros-Alvarez et al. The tethered peptide activation mechanism of adhesion. Nature, . PubMed id: 35418682

Date:

03-Oct-21 Release date: 27-Apr-22

Protein chain

Q9Y653  (AGRG1_HUMAN) -  Adhesion G-protein coupled receptor G1 from Homo sapiens

Seq: 693 a.a.

Struc: 257 a.a.

Protein chain

Q14344  (GNA13_HUMAN) -  Guanine nucleotide-binding protein subunit alpha-13 from Homo sapiens

Seq: 377 a.a.

Struc: 212 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 53 a.a.

* PDB and UniProt seqs differ at 47 residue positions (black crosses)