PDBsum entry 7pyr

Membrane protein

PDB id: 7pyr

Contents

Protein chain

390 a.a.

Ligands

CLR ×3

8IM

OLA ×25

OLC ×4

PEG ×2

Waters ×201

PDB id:

7pyr

Name:

Membrane protein

Title:

Crystal structure of the adenosine a2a receptor (a2a-psb1-bril) in complex with preladenant conjugate psb-2115

Structure:

Adenosine receptor a2a,soluble cytochrome b562,adenosine receptor a2a. Chain: a. Synonym: cytochrome b-562. Engineered: yes. Mutation: yes

Source:

Homo sapiens, escherichia coli. Human. Organism_taxid: 9606, 562. Gene: adora2a, adora2, cybc. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

2.60Å R-factor: 0.200 R-free: 0.252

Authors:

T.Claff,T.A.Klapschinski,U.K.Tiruttani Subhramanyam,V.J.Vaassen, J.G.Schlegel,C.Vielmuth,J.H.Voss,J.Labahn,C.E.Muller

Key ref:

T.Claff et al. Single stabilizing point mutation enables high-Resolu co-Crystal structures of the adenosine a2a receptor w preladenant conjugates.. Angew chem int ed engl, . PubMed id: 35174942

Date:

11-Oct-21 Release date: 02-Mar-22

Protein chain

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 390 a.a.*

Protein chain

P29274  (AA2AR_HUMAN) -  Adenosine receptor A2a from Homo sapiens

Seq: 412 a.a.

Struc: 390 a.a.*

* PDB and UniProt seqs differ at 111 residue positions (black crosses)