PDBsum entry 7f8u

Structural protein

PDB id: 7f8u

Contents

Protein chain

438 a.a.

Ligands

1OE

PDB id:

7f8u

Name:

Structural protein

Title:

Crystal structure of the cholecystokinin receptor cckar in complex with lintitript

Structure:

Fusion protein of cholecystokinin receptor type a and endolysin. Chain: a. Synonym: cck-a receptor,cck-ar,cholecystokinin-1 receptor,cck1-r, lysis protein,lysozyme,muramidase. Engineered: yes

Source:

Homo sapiens, enterobacteria phage t4. Human, bacteriophage t4. Organism_taxid: 9606, 10665. Gene: cckar, cckra. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

2.80Å R-factor: 0.236 R-free: 0.253

Authors:

X.Zhang,C.He,M.Wang,Q.Zhou,D.Yang,Y.Zhu,B.Wu,Q.Zhao

Key ref:

X.Zhang et al. Structures of the human cholecystokinin receptors bou agonists and antagonists.. Nat chem biol, . PubMed id: 34556863

Date:

02-Jul-21 Release date: 13-Oct-21

Protein chain

P00720  (ENLYS_BPT4) -  Endolysin from Enterobacteria phage T4

Seq: 164 a.a.

Struc: 438 a.a.*

Protein chain

P32238  (CCKAR_HUMAN) -  Cholecystokinin receptor type A from Homo sapiens

Seq: 428 a.a.

Struc: 438 a.a.*

* PDB and UniProt seqs differ at 153 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.2.1.17 - lysozyme.
• Reaction: Hydrolysis of the 1,4-beta-linkages between N-acetyl-D-glucosamine and N-acetylmuramic acid in peptidoglycan heteropolymers of the prokaryotes cell walls.