PDBsum entry 7f53

Membrane protein

PDB id: 7f53

Contents

Protein chains

227 a.a.

338 a.a.

57 a.a.

126 a.a.

273 a.a.

13 a.a.

Metals

_CA

Waters ×4

PDB id:

7f53

Name:

Membrane protein

Title:

Cryo-em structure of a-msh-mc4r-gs_nb35 complex

Structure:

Isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Mutation: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Synthetic construct.

Authors:

H.Zhang,L.Chen,C.Mao,Q.Shen,D.Yang,D.Shen,J.Qin

Key ref:

H.Zhang et al. Structural insights into ligand recognition and activ of the melanocortin-4 receptor.. Cell res, . PubMed id: 34433901

Date:

21-Jun-21 Release date: 03-Nov-21

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 227 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 126 a.a.

Protein chain

P32245  (MC4R_HUMAN) -  Melanocortin receptor 4 from Homo sapiens

Seq: 332 a.a.

Struc: 273 a.a.

Protein chain

P01189  (COLI_HUMAN) -  Pro-opiomelanocortin from Homo sapiens

Seq: 267 a.a.

Struc: 13 a.a.

* PDB and UniProt seqs differ at 8 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????