PDBsum entry 7f24

Membrane protein

PDB id: 7f24

Contents

Protein chains

226 a.a.

277 a.a.

341 a.a.

56 a.a.

Ligands

GTP

LDP

PDB id:

7f24

Name:

Membrane protein

Title:

Cryo-em structure of the gtp-bound dopamine receptor 1 and mini-gs complex without nb35

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short,isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein,adenylate cyclase-stimulating g alpha protein. Engineered: yes. Mutation: yes. D(1a) dopamine receptor.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: drd1. Gene: gnb1. Expressed in: trichoplusia ni.

Authors:

T.Xiao,S.Zheng

Key ref:

T.Xiao and s.zheng Structural insight into g protein activation by d1 do receptor. To be published, . PubMed id: 35687690

Date:

10-Jun-21 Release date: 15-Jun-22

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 226 a.a.*

Protein chain

P21728  (DRD1_HUMAN) -  D(1A) dopamine receptor from Homo sapiens

Seq: 446 a.a.

Struc: 277 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 341 a.a.*

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 56 a.a.

* PDB and UniProt seqs differ at 45 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????