PDBsum entry 7f16

Signaling protein

PDB id: 7f16

Contents

Protein chains

376 a.a.

34 a.a.

230 a.a.

338 a.a.

57 a.a.

128 a.a.

Ligands

CLR ×4

PLM ×6

PDB id:

7f16

Name:

Signaling protein

Title:

Cryo-em structure of parathyroid hormone receptor type 2 in complex with a tuberoinfundibular peptide of 39 residues and g protein

Structure:

Parathyroid hormone 2 receptor. Chain: r. Synonym: pth2 receptor. Engineered: yes. Tuberoinfundibular peptide of 39 residues. Chain: p. Synonym: tip39,parathyroid hormone 2. Engineered: yes. Guanine nucleotide-binding protein g(s) subunit alpha

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: pth2r, pthr2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: pth2, tip39, tipf39. Gene: gnas, gnas1, gsp. Rattus norvegicus.

Authors:

X.Wang,X.Cheng,L.H.Zhao,Y.Wang,C.Ye,X.Zou,A.Dai,Z.Cong,J.Chen,Q.Zhou, T.Xia,H.Jiang,H.E.Xu,D.Yang,M.W.Wang

Key ref:

X.Wang et al. (2021). Molecular insights into differentiated ligand recogni the human parathyroid hormone receptor 2.. Proc.Natl.Acad.Sci.Usa, 118, . PubMed id: 34353904 DOI: 10.1073/PNAS.2101279118

Date:

08-Jun-21 Release date: 18-Aug-21

Protein chain

P49190  (PTH2R_HUMAN) -  Parathyroid hormone 2 receptor from Homo sapiens

Seq: 550 a.a.

Struc: 376 a.a.

Protein chain

Q96A98  (TIP39_HUMAN) -  Tuberoinfundibular peptide of 39 residues from Homo sapiens

Seq: 100 a.a.

Struc: 34 a.a.

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 230 a.a.*

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

* PDB and UniProt seqs differ at 8 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????