PDBsum entry 7dw9

Membrane protein

PDB id: 7dw9

Contents

Protein chains

278 a.a.

238 a.a.

341 a.a.

58 a.a.

126 a.a.

233 a.a.

Ligands

CYS-TYR-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2

CLR ×3

PDB id:

7dw9

Name:

Membrane protein

Title:

Cryo-em structure of human v2 vasopressin receptor in complex with an gs protein

Structure:

Vasopressin v2 receptor. Chain: r. Synonym: v2r,avpr v2,antidiuretic hormone receptor,renal-type arginine vasopressin receptor. Engineered: yes. Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: avpr2, adhr, dir, dir3, v2r. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Rattus norvegicus. Rat. Organism_taxid: 10116.

Authors:

F.Zhou,Y.Jiang

Key ref:

F.Zhou et al. (2021). Molecular basis of ligand recognition and activation human v2 vasopressin receptor.. Cell res, 31, 929. PubMed id: 33742150

Date:

15-Jan-21 Release date: 21-Jul-21

Protein chain

P30518  (V2R_HUMAN) -  Vasopressin V2 receptor from Homo sapiens

Seq: 371 a.a.

Struc: 278 a.a.

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 238 a.a.*

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 238 a.a.*

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 341 a.a.

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 58 a.a.

Protein chain

No UniProt id for this chain

Struc: 126 a.a.

Protein chain

No UniProt id for this chain

Struc: 233 a.a.

* PDB and UniProt seqs differ at 217 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????