PDBsum entry 7dty

Structural protein

PDB id: 7dty

Contents

Protein chains

367 a.a.

30 a.a.

232 a.a.

341 a.a.

57 a.a.

129 a.a.

Ligands

CLR ×6

PDB id:

7dty

Name:

Structural protein

Title:

Structural basis of ligand selectivity conferred by the human glucose- dependent insulinotropic polypeptide receptor

Structure:

Human glucose-dependent insulinotropic polypeptide receptor. Chain: r. Engineered: yes. Other_details: mutations:1. Gastric inhibitory polypeptide. Chain: p. Synonym: gip,glucose-dependent insulinotropic polypeptide,incretin hormone.

Source:

Homo sapiens. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Human. Bos taurus. Bovine. Organism_taxid: 9913.

Authors:

F.H.Zhao,C.Zhang,Q.T.Zhou,K.N.Hang,X.Y.Zou,Y.Chen,F.Wu,Q.D.Rao, A.T.Dai,W.C.Yin,D.D.Shen,Y.Zhang,T.Xia,R.C.Stevens,H.E.Xu,D.H.Yang, L.H.Zhao,M.W.Wang

Key ref:

F.Zhao et al. (2021). Structural insights into hormone recognition by the h glucose-Dependent insulinotropic polypeptide receptor. Elife, 10, . PubMed id: 34254582

Date:

06-Jan-21 Release date: 04-Aug-21

Protein chain

P48546  (GIPR_HUMAN) -  Gastric inhibitory polypeptide receptor from Homo sapiens

Seq: 466 a.a.

Struc: 367 a.a.*

Protein chain

P09681  (GIP_HUMAN) -  Gastric inhibitory polypeptide from Homo sapiens

Seq: 153 a.a.

Struc: 30 a.a.

Protein chain

P04896  (GNAS2_BOVIN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Bos taurus

Seq: 394 a.a.

Struc: 232 a.a.*

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 341 a.a.

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 129 a.a.

* PDB and UniProt seqs differ at 9 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????