PDBsum entry 7cx4

Membrane protein

PDB id: 7cx4

Contents

Protein chains

266 a.a.

228 a.a.

340 a.a.

58 a.a.

128 a.a.

Ligands

GM9

PDB id:

7cx4

Name:

Membrane protein

Title:

Cryo-em structure of the evatanepag-bound ep2-gs complex

Structure:

Prostaglandin e2 receptor ep2 subtype. Chain: r. Synonym: pge2 receptor ep2 subtype,prostanoid ep2 receptor. Engineered: yes. Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ptger2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell: sf9. Gene: gnas, gnas1, gsp. Gene: gnb1.

Authors:

C.Qu,C.Mao,P.Xiao,Q.Shen,Y.Zhong,F.Yang,D.Shen,X.Tao,H.Zhang,X.Yan, R.Zhao,J.He,Y.Guan,C.Zhang,G.Hou,P.Zhang,X.Yu,Y.Guan,J.Sun,Y.Zhang

Key ref:

C.Qu et al. (2021). Ligand recognition, Unconventional activation, And g coupling of the prostaglandin e 2 receptor ep2 subtyp. Sci adv, 7, . PubMed id: 33811074

Date:

01-Sep-20 Release date: 05-May-21

Protein chain

P43116  (PE2R2_HUMAN) -  Prostaglandin E2 receptor EP2 subtype from Homo sapiens

Seq: 358 a.a.

Struc: 266 a.a.

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 228 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 340 a.a.*

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 58 a.a.

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

* PDB and UniProt seqs differ at 9 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????