PDBsum entry 7bz2

Signaling protein

PDB id: 7bz2

Contents

Protein chains

198 a.a.

331 a.a.

37 a.a.

127 a.a.

285 a.a.

Ligands

H98

PDB id:

7bz2

Name:

Signaling protein

Title:

Cryo-em structure of the formoterol-bound beta2 adrenergic receptor-gs protein complex.

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Bos taurus. Bovine. Organism_taxid: 9913.

Authors:

Y.N.Zhang,F.Yang,S.L.Ling,P.Lv,Y.X.Zhou,W.Fang,W.Sun,P.Shi,C.L.Tian

Key ref:

Y.Zhang et al. (2020). Single-particle cryo-EM structural studies of the β₂AR-Gs complex bound with a full agonist formoterol. Cell Discov, 6, 45. PubMed id: 32655881 DOI: 10.1038/s41421-020-0176-9

Date:

26-Apr-20 Release date: 05-Aug-20

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 198 a.a.*

Protein chain

P62871  (GBB1_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Bos taurus

Seq: 340 a.a.

Struc: 331 a.a.*

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 37 a.a.

Protein chain

No UniProt id for this chain

Struc: 127 a.a.

Protein chain

P07550  (ADRB2_HUMAN) -  Beta-2 adrenergic receptor from Homo sapiens

Seq: 413 a.a.

Struc: 285 a.a.*

* PDB and UniProt seqs differ at 54 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????

DOI no: 10.1038/s41421-020-0176-9

Cell Discov 6:45 (2020)

PubMed id: 32655881

Single-particle cryo-EM structural studies of the β₂AR-Gs complex bound with a full agonist formoterol.

Y.Zhang, F.Yang, S.Ling, P.Lv, Y.Zhou, W.Fang, W.Sun, L.Zhang, P.Shi, C.Tian.

ABSTRACT

No abstract given.