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UniProt functional annotation for Q9Y3C6 | ||
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| UniProt code: Q9Y3C6. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:16595688). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:16595688, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}. |
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| Catalytic activity: | |
Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence={ECO:0000269|PubMed:16595688}; |
| Activity regulation: | |
Inhibited by Cyclosporin A. {ECO:0000269|PubMed:16595688}. |
| Biophysicochemical properties: | |
Kinetic parameters: KM=230 uM for N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide {ECO:0000269|PubMed:16595688}; |
| Subunit: | |
Identified in the spliceosome C complex (PubMed:11991638, PubMed:28502770, PubMed:28076346). Interacts with SNW1 (PubMed:16595688, PubMed:20368803). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:16595688, ECO:0000269|PubMed:20368803, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}. |
| Tissue specificity: | |
Ubiquitous, with the most abundant expression in heart and skeletal muscle. |
| Similarity: | |
Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.