UniProt functional annotation for Q86X95



	UniProt functional annotation for Q86X95

UniProt code: Q86X95.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription. {ECO:0000250, ECO:0000269|PubMed:19409814, ECO:0000269|PubMed:9874765}.

Subunit: Interacts with RP9, SNW1, SFRS1, SFRS2,U2AF1, RBPJ, SAP30, HDAC2 NKAP and NEK6. Interacts with Epstein-Barr virus RPMS1. Component of the histone deacetylase complex. Component of the Notch corepressor complex. Interacts with NKAPL (By similarity). {ECO:0000250|UniProtKB:Q9DA19, ECO:0000269|PubMed:10644367, ECO:0000269|PubMed:11222720, ECO:0000269|PubMed:19409814, ECO:0000269|PubMed:20873783, ECO:0000269|PubMed:9874765}.

Subcellular location: Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome.

Tissue specificity: Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas. {ECO:0000269|PubMed:9874765}.

Ptm: Phosphorylated by NEK6. {ECO:0000269|PubMed:20873783}.

Miscellaneous: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.

Sequence caution: Sequence=AAA17853.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH21175.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH38987.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription. {ECO:0000250, ECO:0000269\|PubMed:19409814, ECO:0000269\|PubMed:9874765}.


Subunit:		Interacts with RP9, SNW1, SFRS1, SFRS2,U2AF1, RBPJ, SAP30, HDAC2 NKAP and NEK6. Interacts with Epstein-Barr virus RPMS1. Component of the histone deacetylase complex. Component of the Notch corepressor complex. Interacts with NKAPL (By similarity). {ECO:0000250\|UniProtKB:Q9DA19, ECO:0000269\|PubMed:10644367, ECO:0000269\|PubMed:11222720, ECO:0000269\|PubMed:19409814, ECO:0000269\|PubMed:20873783, ECO:0000269\|PubMed:9874765}.
Subcellular location:		Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome.
Tissue specificity:		Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas. {ECO:0000269\|PubMed:9874765}.
Ptm:		Phosphorylated by NEK6. {ECO:0000269\|PubMed:20873783}.
Miscellaneous:		[Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.
Sequence caution:		Sequence=AAA17853.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH21175.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH38987.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};