UniProt functional annotation for Q9NS87



	UniProt functional annotation for Q9NS87

UniProt code: Q9NS87.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. {ECO:0000250}.

Subunit: Interacts with MKI67 and TPX2. {ECO:0000269|PubMed:10878014, ECO:0000269|PubMed:12612055}.

Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Detected during the interphase in the cytoplasm as finely punctuate pattern and irregularly shaped dots. Detected during mitosis on the mitotic spindle. Colocalizes with TPX2 in mitosis. Localizes at the central spindle at anaphase (By similarity). Localizes at the sites of invaginating cell membranes, a position that corresponds to the location of the contractile actomyosin ring of dividing cells (By similarity). Colocalizes with actin in interphase (By similarity). Colocalizes in dendrites and in growth cone of axons with microtubules (By similarity). {ECO:0000250}.

Tissue specificity: Expressed in testis, colon, thymus and in breast cancer. {ECO:0000269|PubMed:12747765}.

Similarity: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KLP2 subfamily. {ECO:0000255|PROSITE- ProRule:PRU00283}.

Sequence caution: Sequence=AAG48261.1; Type=Frameshift; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. {ECO:0000250}.


Subunit:		Interacts with MKI67 and TPX2. {ECO:0000269\|PubMed:10878014, ECO:0000269\|PubMed:12612055}.
Subcellular location:		Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Detected during the interphase in the cytoplasm as finely punctuate pattern and irregularly shaped dots. Detected during mitosis on the mitotic spindle. Colocalizes with TPX2 in mitosis. Localizes at the central spindle at anaphase (By similarity). Localizes at the sites of invaginating cell membranes, a position that corresponds to the location of the contractile actomyosin ring of dividing cells (By similarity). Colocalizes with actin in interphase (By similarity). Colocalizes in dendrites and in growth cone of axons with microtubules (By similarity). {ECO:0000250}.
Tissue specificity:		Expressed in testis, colon, thymus and in breast cancer. {ECO:0000269\|PubMed:12747765}.
Similarity:		Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KLP2 subfamily. {ECO:0000255\|PROSITE- ProRule:PRU00283}.
Sequence caution:		Sequence=AAG48261.1; Type=Frameshift; Evidence={ECO:0000305};