UniProt functional annotation for P20789



	UniProt functional annotation for P20789

UniProt code: P20789.

Organism: Rattus norvegicus (Rat).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.

Function: G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:23051748, PubMed:24453215, PubMed:26205105). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (By similarity). {ECO:0000250|UniProtKB:P30989, ECO:0000269|PubMed:1694443, ECO:0000269|PubMed:23051748, ECO:0000269|PubMed:24453215, ECO:0000269|PubMed:26205105}.

Subunit: Interacts (palmitoylated form) with GNA11. {ECO:0000250|UniProtKB:P30989}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:1694443, ECO:0000269|PubMed:24453215, ECO:0000269|PubMed:26205105}; Multi-pass membrane protein {ECO:0000269|PubMed:1694443, ECO:0000269|PubMed:24453215, ECO:0000269|PubMed:26205105}. Membrane raft {ECO:0000250|UniProtKB:P30989}. Note=Palmitoylation is required for localization at CAV1-enriched membrane rafts. {ECO:0000250|UniProtKB:P30989}.

Tissue specificity: Detected in brain and small intestine. {ECO:0000269|PubMed:1694443}.

Domain: The ligand binding pocket consists mainly of extracellular loops ECL2 and ECL3, as well as transmembrane regions TM6 and TM7. {ECO:0000269|PubMed:23051748, ECO:0000269|PubMed:26205105}.

Ptm: N-glycosylated. {ECO:0000250|UniProtKB:P30989}.

Ptm: Palmitoylated; this is required for normal localization at membrane rafts and normal GNA11-mediated activation of down-stream signaling cascades. The palmitoylation level increases in response to neurotensin treatment. {ECO:0000250|UniProtKB:P30989}.

Similarity: Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.

Annotations taken from UniProtKB at the EBI.


Organism:		Rattus norvegicus (Rat).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.



Function:		G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:23051748, PubMed:24453215, PubMed:26205105). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (By similarity). {ECO:0000250\|UniProtKB:P30989, ECO:0000269\|PubMed:1694443, ECO:0000269\|PubMed:23051748, ECO:0000269\|PubMed:24453215, ECO:0000269\|PubMed:26205105}.


Subunit:		Interacts (palmitoylated form) with GNA11. {ECO:0000250\|UniProtKB:P30989}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:1694443, ECO:0000269\|PubMed:24453215, ECO:0000269\|PubMed:26205105}; Multi-pass membrane protein {ECO:0000269\|PubMed:1694443, ECO:0000269\|PubMed:24453215, ECO:0000269\|PubMed:26205105}. Membrane raft {ECO:0000250\|UniProtKB:P30989}. Note=Palmitoylation is required for localization at CAV1-enriched membrane rafts. {ECO:0000250\|UniProtKB:P30989}.
Tissue specificity:		Detected in brain and small intestine. {ECO:0000269\|PubMed:1694443}.
Domain:		The ligand binding pocket consists mainly of extracellular loops ECL2 and ECL3, as well as transmembrane regions TM6 and TM7. {ECO:0000269\|PubMed:23051748, ECO:0000269\|PubMed:26205105}.
Ptm:		N-glycosylated. {ECO:0000250\|UniProtKB:P30989}.
Ptm:		Palmitoylated; this is required for normal localization at membrane rafts and normal GNA11-mediated activation of down-stream signaling cascades. The palmitoylation level increases in response to neurotensin treatment. {ECO:0000250\|UniProtKB:P30989}.
Similarity:		Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily. {ECO:0000255\|PROSITE-ProRule:PRU00521}.